The Great Sandhills Railway (reporting mark GSR) is a Canadian short-line railway company that operates 123 miles (198 km) of track west of Swift Current, Saskatchewan in the provinces of Saskatchewan and Alberta. The railway began operations on March 14, 2009. Great Sandhills Railway owns and operates on the former Canadian Pacific Railway's Empress Subdivision, Burstall Subdivision and Hazlet Spur (collectively known as the Empress Short Line).

The railway serves freight stations in Burstall, Mendham, Leader, Prelate, Sceptre, Portreeve, Lancer, Abbey, Cabri, Battrum, Pennant, Success, Cantuar, and Swift Current. It interchanges with both the Canadian Pacific Railway and the Great Western Railway in Swift Current, via running rights on CP's Maple Creek Subdivision between Mayne and Swift Current. The railway hauls grain from terminals, elevators and producer loading sites, and also moves products from the Empress Gas plants in Alberta.